SST0116CL1 - CAS 1799802-29-1

SST0116CL1 is an HSP90 inhibitor (IC50: 0.21 μM) that targets the ATP-binding pocket of Hsp90, disrupting its chaperone function and leading to the degradation of client proteins (EGFR, CDK4, and AKT) . It induces the degradation of Her2 in BT-474 cells (IC50: 0.2 μM) and exhibits antiproliferative activity, inhibiting tumor growth.

EGFR, HSP, Akt, CDK

Metabolism, Cytoskeletal Signaling, Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors, PI3K/Akt/mTOR signaling, Cell Cycle/Checkpoint

1799772

C22H31ClN4O6

482.96

Cl.O=C(NCC)C1=NOC(C=2C=C(C(O)=CC2O)C(C)C)=C1NC(=O)CCN3CCOCC3

-20°C

Ice Packs

Small Compound