ST-899 - CAS 143484-41-7

ST-899 is an innovative platelet-activating factor (PAF) receptor antagonist. It significantly reduces the mortality rate in mice experiencing shock induced by endotoxins (LPS) . The compound markedly inhibits the LPS-induced increase in serum tumor necrosis factor (TNF) levels while leaving interleukin-6 (IL-6) unaffected. The mechanism by which ST-899 operates involves disrupting the positive feedback loop between PAF and TNF, thereby mitigating inflammatory responses. ST-899 is applicable for studies related to inflammatory diseases such as septic shock.

TNF, PAFR

Apoptosis, GPCR/G Protein

143436

C22H29BrClNO6

518.83

C(\COC(C[C@@H](OC(CC(C)C)=O)C[N+](C)(C)C)=O)=C\1/C=2C(C(=O)O1)=CC=C(Cl)C2.[Br-]

-20°C

Ice Packs

Small Compound