StA-IFN-1 - CAS 300839-31-0

StA-IFN-1 is an inhibitor of the interferon (IFN) induction pathway with an IC50 value of 4.1 μM in a GFP reporter assay for IFN induction similar to TPCA-1 , which specifically inhibits the IKKβ component of the IFN induction pathway. It does not show inhibitory activity in a GFP reporter assay for IFN signaling in which ruxolitinib , which is specific for the IFN signaling component JAK1, is active. StA-IFN-1 reduces the levels of IFN-β, but not ISG MxA, mRNA, suggesting that it is selective for the IFN induction pathway and not the IFN signaling pathway.

Others, IFNAR

Immunology/Inflammation, Others

300808

C14H13N3O2

255.27

CC(=O)n1cc(C2C(=O)NN=C2C)c2ccccc12

-20°C

Ice Packs

Small Compound