STAT1/3-IN-1 - CAS 2958649-56-2

STAT1/3-IN-1 (Compound 6k) is an inhibitor of STAT1/3 phosphorylation. It prevents the phosphorylation and nuclear translocation of STAT1/3. Additionally, STAT1/3-IN-1 inhibits the inflammatory enzymes iNOS and COX-2. This compound exhibits anti-inflammatory properties by reducing pro-inflammatory cytokines, such as IL-1β, IL-6, and TNF-α, without significant cytotoxicity.

COX, STAT, Interleukin, NO Synthase

Neuroscience, JAK/STAT signaling, Stem Cells, Immunology/Inflammation

2958591

C28H25ClN6O5

560.988

O(C)C1=C2N(C[C@]3(N(C2=O)[C@H](C)CCO3)[H])C=C(C(NC4=CC(=CC=C4)C5=CN(N=N5)C6=C(Cl)C=CC=C6)=O)C1=O

-20°C

Ice Packs

Small Compound