STAT3/CAIX-IN-1 - CAS 3053583-60-8

STAT3/CAIX-IN-1 is a dual-target inhibitor of STAT3 (Kd: 60.03 μM) and CAIX (IC50: 80.45 nM) . It induces ferroptosis by elevating reactive oxygen species (ROS) and lipid peroxides. This compound also inhibits cell migration, induces apoptosis, and causes cell cycle arrest in MDA-MB-231 cells. STAT3/CAIX-IN-1 is applicable for research in triple-negative breast cancer (TNBC) .

ROS, STAT, Carbonic Anhydrase, Apoptosis, Ferroptosis, Bcl-2 Family, Caspase

Apoptosis, Immunology/Inflammation, Metabolism, JAK/STAT signaling, Proteases/Proteasome, Stem Cells

3053515

C28H23F6N5O5S2

687.63

C(=C\1/C(=O)\C(=C\C2=CC=C(C(F)(F)F)C=C2)\CN(C(CCCC(NC=3SC(S(N)(=O)=O)=NN3)=O)=O)C1)\C4=CC=C(C(F)(F)F)C=C4

-20°C

Ice Packs

Small Compound