Stephacidin B - CAS 360765-75-9

Stephacidin B is a fungal metabolite that has been found inA. ochraceus.1Dimeric stephacidin B is rapidly converted to a monomer, avrainvillamide , in vitro.2Stephacidin B is cytotoxic to a variety of cancer cells, including testosterone-independent PC3 and -sensitive LNCaP prostate cancer cells (IC50s = 0.37 and 0.06 μM, respectively) and estradiol-independent SK-BR-3 and -sensitive MCF-7 breast cancer cells (IC50s = 0.32 and 0.27 μM, respectively) .1It induces apoptosis in HepG2 and Huh7 hepatocellular carcinoma cells when used at a concentration of 4 μM.3

Others, Endogenous Metabolite

Metabolism, Others

360681

C52H54N6O8

891.038

[H][C@@]12N3C(=O)[C@@]45CCCN4C(=O)[C@@]33[C@@]([H])(c4c(n(O)c6c7C=CC(C)(C)Oc7ccc46)C(C)(C)[C@]3([H])C5)[C@]11C(=N(=O)c3c1ccc1OC(C)(C)C=Cc31)C(C)(C)[C@]1([H])C[C@]34CCCN3C(=O)[C@]21NC4=O |c:23,59,@:2,THB:31:34:2.3:9.10|

-20°C

Ice Packs

Natural Product