STING Agonist 1a - CAS 652142-94-4

STING agonist 1a is an agonist of stimulator of interferon genes (STING) .1It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50= 16.77 μM) . STING agonist 1a (12.5-100 μM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .

Others, STING

Others, Immunology/Inflammation

652044

C19H11Cl2N5O

396.23

ClC=1C=2N(C(=NN2)C3=CC4=C(N=C3Cl)C=CC(OC)=C4)C=5C(N1)=CC=CC5

-20°C

Ice Packs

Small Compound