SU-11752 - CAS 688036-19-3

SU-11752 is a potent and selective DNA-PK inhibitor. Inhibition kinetics and a direct assay for ATP binding showed that SU11752 inhibited DNA-PK by competing with ATP. SU11752 inhibited DNA double-strand break repair in cells and gave rise to a five-fold sensitization to ionizing radiation. At concentrations of SU11752 that inhibited DNA repair, cell cycle progression was still normal and ATM kinase activity was not inhibited.

Others, PI3K, DNA-PK

Others, PI3K/Akt/mTOR signaling, DNA Damage/DNA Repair

688014

C26H27N3O5S

493.57

C(=C1C=2C(NC1=O)=CC=C(S(NC3=CC=CC=C3)(=O)=O)C2)C4=C(CC)C(CCC(O)=O)=C(CC)N4

-20°C

Ice Packs

Small Compound