Sulfo-ara-F-NMN - CAS 1374663-29-2

Sulfo-ara-F-NMN is an analogue of nicotinamide mononucleotide (NMN) with cellular permeability. Sulfo-ara-F-NMN was selective to activate SARM1 and inhibited CD38 with an IC50 of about 10 μM. Activation by Sulfo-ara-F-NMN to Z-48 or NMN, which has a higher cyclase activity, causes conformational changes in SARM1, resulting in cADPR production, NAD depletion, and non-apoptotic cell death.

Others, TLR

Immunology/Inflammation, Others

1374632

C11H14FN2O6PS

352.28

F[C@@H]1[C@@H](O[C@H](COP(=O)([O-])S)[C@H]1O)[N+]=2C=C(C(N)=O)C=CC2

-20°C

Ice Packs

Small Compound