Sulindac - CAS 38194-50-2

Sulindac (Sulindac sulfoxide) is a sulfinylindene derivative prodrug with potential antineoplastic activity. Converted in vivo to an active metabolite, sulindac, a nonsteroidal anti-inflammatory drug (NSAID), blocks cyclic guanosine monophosphate-phosphodiesterase (cGMP-PDE), an enzyme that inhibits the normal apoptosis signal pathway; this inhibition permits the apoptotic signal pathway to proceed unopposed, resulting in apoptotic cell death.

NF-κB, PD-1/PD-L1, COX, Autophagy

Cell Cycle/Checkpoint, Neuroscience, NF-κB, Autophagy, Apoptosis, Immunology/Inflammation

38142

0.9949

C20H17FO3S

356.41

C(=C/1\C=2C(C(CC(O)=O)=C1C)=CC(F)=CC2)\C3=CC=C(S(C)=O)C=C3

-20°C

Ice Packs

Small Compound