SUN-1334H free base - CAS 607737-00-8

SUN-1334H free base, an orally active histamine H1 receptor inhibitor, exhibits a K_i of 9.7 nM and an IC 50 of 20.3 nM. Additionally, it effectively prevents histamine-induced contractions in isolated guinea-pig ileum with an IC 50 of 0.198 μM. The compound also blocks histamine-induced bronchoconstriction and skin wheals in guinea pigs and beagle dogs, respectively, and mitigates ovalbumin-induced rhinitis in guinea pigs.

Dopamine Receptor, Histamine Receptor, Sigma receptor, Adrenergic Receptor

GPCR/G Protein, Immunology/Inflammation, Neuroscience

607737-00-8

C23H26F2N2O3

416.46

C(N1CCN(C/C=C/COCC(O)=O)CC1)(C2=CC=C(F)C=C2)C3=CC=C(F)C=C3

-20°C

Ice Packs

Small Compound