SUN-C5174 - CAS 191592-36-6

SUN-C5174 is a sleective 5-HT2 antagonist (pA2=8.98+/-0.06) . SUN C5174 showed a marked inhibitory effect on the platelet aggregation induced by serotonin in combination with collagen and adenosine diphosphate (ADP) in canine or human platelet-rich plasma (IC50=6.5 to 16 nM) . SUN-C5174 significantly inhibited the mortality rate in mouse acute pulmonary thromboembolytic death induced by collagen and serotonin at oral doses of 0.3 mg/kg or higher.

Others, 5-HT Receptor

GPCR/G Protein, Neuroscience, Others

191550

C22H29FN4O2

400.49

CN1C2=C(C(=O)N(CCCN3CCN(CC3)C4=CC=C(F)C=C4)CC[C@@H]2O)C=C1

-20°C

Ice Packs

Small Compound