Surfen dihydrochloride - CAS 5424-37-3

Surfen dihydrochloride (Aminoquinuride dihydrochloride) is a potent small molecule antagonist of heparin sulfate with antibacterial and antiviral activity, and inhibits anthrax lethal factor, coagulation factor X, and lethal factor.Surfen inhibits the anticoagulant activity of both normal and low-molecular-weight heparin and inhibits heparin sulfation and heparin cleavage enzyme degradation.Surfen inhibits the blockade of FGF2 binding and signaling mediated by heparin acetylsulfate. Surfen inhibits the blockade of acetylheparin sulfate-mediated FGF2 binding and signaling.Surfen inhibits SEVI and semen-mediated enhancement of HIV type 1 infection.

Antibiotic, Antiviral, FGFR, VEGFR, HSV, Microtubule Associated

Cytoskeletal Signaling, Angiogenesis, Tyrosine Kinase/Adaptors, Microbiology/Virology, Immunology/Inflammation

5384

0.9708

C21H22Cl2N6O

445.35

Cl.Cl.Cc1cc(N)c2cc(NC(=O)Nc3ccc4nc(C)cc(N)c4c3)ccc2n1

-20°C

Ice Packs

Small Compound