SX-517 - CAS 1240494-13-6

SX-517 is a non-competitive dual antagonist of CXCR1/2, demonstrating anti-inflammatory effects in both PMN cells and mouse models. SX-517 inhibits CXCL-1-induced Ca2+ flux (IC50 = 38 nM), antagonises CXCL-8-induced [ (35) S]GTPγS binding (IC50 = 60 nM), and suppresses ERK1/2 phosphorylation.

CXCR

GPCR/G Protein, Immunology/Inflammation, Autophagy

1240475

C19H16BFN2O3S

382.22

O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC=3C=CC=CC3B(O)O)C=C2

-20°C

Ice Packs

Small Compound