Syk Inhibitor II dihydrochloride - CAS 227449-73-2

Spleen tyrosine kinase (Syk) is a non-receptor tyrosine kinase that, upon phosphorylation, binds to immunoreceptor tyrosine-based activation motifs of FcRγ chains and mediates downstream signaling related to platelet function and inflammation. Syk inhibitor II is a cell-permeable, pyrimidine-carboxamide compound that selectively and reversibly blocks Syk (IC50 = 41 nM) in an ATP-competitive manner. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk (IC50s = 5.1, 11, 11.2, 15.5, and 22.6 μM, respectively) .

5-HT Receptor, BTK, PKC, Tyrosine Kinases, Syk

Angiogenesis, Neuroscience, Cytoskeletal Signaling, GPCR/G Protein, Tyrosine Kinase/Adaptors, Chromatin/Epigenetic

227374

>99.99%

C14H17Cl2F3N6O

413.22

Cl.Cl.NCCNc1ncc(C(N)=O)c(Nc2cccc(c2)C(F)(F)F)n1

-20°C

Ice Packs

Small Compound