Syntelin - CAS 438481-33-5

Syntelin is a selectively CENP-E inhibitor. Syntelin inhibited CENP-E motility in a dose-dependent manner with an IC50 value of 160 nM. Among an extensive list of mitotic kinesins examined, syntelin was found to be highly selective for CENP-E. Syntelin binds to different sites from those of GSK923295, a recently identified CENP-E ATPase inhibitor, as syntelin inhibits CENP-E mutants resistant to GSK923295 in a manner indistinguishable from that of wild type motor. Syntelin represents a novel class of CENP-E motor inhibitor.

Kinesin, Others

Cytoskeletal Signaling, Others

438443

C21H20N6O2S3

484.62

NC1=NC(SCC2=NN=C(SCC(O)=O)N2C2=CC=CC=C2)=NC2=C1C1=C(CCCC1)S2

-20°C

Ice Packs

Small Compound