SZM-1209 - CAS 2919801-86-6

SZM-1209 is a potent and specific RIPK1 inhibitor with oral activity, displaying a dissociation constant (Kd) of 85 nM. It demonstrates substantial anti-necroptotic efficacy with an EC50 of 22.4 ± 8.1 nM and possesses therapeutic effects against systemic inflammatory response syndrome (SIRS) and acute lung injury (ALI) [1].

MLK, Necroptosis, RIP kinase

NF-κB, Apoptosis, MAPK

2919709

C31H29F5N4O5S2

696.71

-20°C

Ice Packs

Small Compound