SZUH280 - CAS 2770263-77-7

SZUH280 is a potent, selective PROTAC (proteolysis targeting chimera) HDAC8 (histone deacetylase 8) degrader, demonstrating a DC50 of 0.58 μM in A549 cells. It induces apoptosis in cancer cells and impedes DNA damage repair, thereby enhancing cellular radiosensitization [1].

PROTACs, Apoptosis, Others, DNA/RNA Synthesis, HDAC

Chromatin/Epigenetic, Apoptosis, Cell Cycle/Checkpoint, Others, DNA Damage/DNA Repair, PROTAC

2770179

C36H34N8O8

706.7

N(CC1=CN(CCOCCOC2=CC=C(CN3C=4C(C=C3)=CC=C(C(NO)=O)C4)C=C2)N=N1)C5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5

-20°C

Ice Packs

PROTAC