T-2513 - CAS 288247-87-0

T-2513 is a potent and specific inhibitor of topoisomerase I. It acts by forming covalent bonds with the topoisomerase I-DNA complex, thereby enhancing its stability. This interaction disrupts the normal process of DNA replication and RNA synthesis, ultimately resulting in cellular apoptosis.

Others, DNA/RNA Synthesis, Topoisomerase

DNA Damage/DNA Repair, Cell Cycle/Checkpoint, Others

288160

C25H27N3O5

449.507

CCc1c2Cn3c(cc4c(COC(=O)[C@]4(O)CC)c3=O)-c2nc2ccc(OCCCN)cc12

-20°C

Ice Packs

Small Compound