T-Boc-N-amido-PEG4-Val-Cit - CAS 2231240-82-5

T-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker, featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is susceptible to cleavage by cellular proteases and contains a free carboxylic acid that can couple with amines to form amides. The Boc group can be removed under acidic conditions to reveal a free primary amine, which is useful for various reactions, such as conjugation or reductive amination.

ADC Linker

Antibody-drug Conjugate/ADC Related

2231240-82-5

C27H51N5O11

621.721

[C@H](C(N[C@@H](CCCNC(N)=O)C(O)=O)=O)(NC(CCOCCOCCOCCOCCNC(OC(C)(C)C)=O)=O)[C@@H](C)C

-20°C

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