Talaroconvolutin A - CAS 273199-42-1

Talaroconvolutin A is an inducer of ferroptosis (ferroptosis) that operates by elevating reactive oxygen species (ROS) levels instead of acting through the GPX4 pathway. It decreases the expression of the solute carrier family 7 member 11 (SLC7A11) and increases the expression of arachidonate lipoxygenase 3 (ALOXE3) . This compound inhibits the growth of colorectal cancer cells HCT116 and bladder cancer cells SW480, with IC50 values of 1.22 μM and 1.4 μM, respectively. Talaroconvolutin A is applicable in studies related to colorectal and bladder cancers.

ROS, p38 MAPK, Ferroptosis

MAPK, Immunology/Inflammation, Apoptosis

273199-42-1

C32H41NO3

487.67

C(=O)([C@H]1[C@]2([C@](C)(C=C(C)[C@H]1\C(=C\[C@H](CC)C)\C)C[C@H](C)CC2)[H])C3=C\C(=C\C4=CC=C(O)C=C4)\NC3=O

-20°C

Ice Packs

Natural Product