Taletrectinib free base - CAS 1505514-27-1

Taletrectinib free base (AB-106 free base) is a novel potent, selective and orally active ROS1/NTRK inhibitor.Taletrectinib free base has potent inhibitory effects on recombinant ROS1, NTRK1, NTRK2, and NTRK3, with IC50s of 0.207, 0.622, 2.28 and 0.98 nM, respectively, Taletrectinib free base also inhibited ROS1 G2032R and other Crizotinib-resistant ROS1 mutations.

ROS Kinase

Tyrosine Kinase/Adaptors

1505486

0.9998

C23H24FN5O

405.47

N([C@H](C)C1=CC(F)=CC=C1)C2=NN3C(=CN=C3C=C2)C4=CC=C(OC[C@@H](C)N)C=C4

-20°C

Ice Packs

Small Compound