Talniflumate - CAS 66898-62-2

Talniflumate (Somalgen) is a calcium-activated chloride channel (hCLCA1/mCLCA3) blocker that reduces mucin synthesis and releases in animal models and cell culture. It possesses anti-inflammatory actions via inhibition of Cox (cyclooxygenase) and inhibits Cl-/HCO3- exchange activity. It also increases survival in a cystic fibrosis mouse model of the distal intestinal obstructive syndrome.

COX, Anion Exchanger, Chloride channel, N-Acetylglucosaminyltransferase

Immunology/Inflammation, Membrane transporter/Ion channel, Neuroscience, Metabolism

66834

0.9993

C21H13F3N2O4

414.33

O(C(=O)C1=C(NC2=CC(C(F)(F)F)=CC=C2)N=CC=C1)C3C=4C(C(=O)O3)=CC=CC4

-20°C

Ice Packs

Small Compound