Talotrexin - CAS 113857-87-7

Talotrexin (PT523), an analog of Aminopterin, is a nonpolyglutamatable classic antifolate that specifically inhibits the reduced folate carrier (RFC), selectively impeding RFC transport and targeting dihydrofolate reductase (DHFR) to demonstrate antitumor activity and inhibit tumor growth [1] [2].

DHFR, Others, Antifolate

Cell Cycle/Checkpoint, Metabolism, Others, DNA Damage/DNA Repair

113763

C27H27N9O6

573.56

NC=1C2=C(N=CC(CNC3=CC=C(C(N[C@@H](CCCNC(=O)C4=C(C(O)=O)C=CC=C4)C(O)=O)=O)C=C3)=N2)N=C(N)N1

-20°C

Ice Packs

Small Compound