TAME - CAS 901-47-3

TAME (Tosyl-Arginine Methyl Este), an inhibitor of the late-promoting complex (APC/C or APC), inhibits APC-dependent protein hydrolysis by competing for APC binding with the C-terminal isoleucine-arginine tail of the APC activator cytokinesis cycle 20 (Cdc20) . TAME binds to and prevents APC binding by Cdc20 and Cdh20. TAME binds to APC and prevents its activation by Cdc20 and Cdh1.

APC/C

Cell Cycle/Checkpoint

851

C14H22N4O4S

342.41

S(N[C@@H](CCCNC(=N)N)C(OC)=O)(=O)(=O)C1=CC=C(C)C=C1

-20°C

Ice Packs

Peptide