Taminadenant mesylate - CAS 2253894-81-2

Taminadenant, also known as PBF-509 and NIR-178, is a potent and orally active adenosine A2A receptor antagonist with potential antineoplastic activity. PBF-509 selectively binds to and inhibits A2AR expressed on T lymphocytes. This abrogates the adenosine/A2AR-mediated inhibition of T-lymphocytes and activates a T-cell-mediated immune response against tumor cells, thereby reducing proliferation of susceptible tumor cells. A2AR, a G protein-coupled receptor, is highly expressed on the cell surfaces of T-cells and, upon activation by adenosine, inhibits their proliferation and activation. Adenosine is often produced in excess by cancer cells.

Others, Adenosine Receptor

GPCR/G Protein, Neuroscience, Others

2253811

C11H12BrN7O3S

402.227

CS(O)(=O)=O.Nc1nc(nc(c1Br)-n1cccn1)-n1cccn1

-20°C

Ice Packs

Small Compound