Tanimilast - CAS 1239278-59-1

Tanimilast (CHF-6001) is a novel, potent, and selective phosphodiesterase 4 inhibitor with an IC50 value of 0.026 ± 0.006 nM. It exhibits potent anti-inflammatory activity and is indicated for topical use in the lungs. Tanimilast was studied for its effects on obstructive lung disease.

PDE, CXCR, CCR, Interleukin, NF-κB, TNF

Immunology/Inflammation, NF-κB, GPCR/G Protein, Metabolism, Apoptosis, Autophagy, Microbiology/Virology

1239218

0.9918

C30H30Cl2F2N2O8S

687.54

[C@@H](CC=1C(Cl)=CN(=O)=CC1Cl)(OC(=O)C2=CC(OCC3CC3)=C(NS(C)(=O)=O)C=C2)C4=CC(OCC5CC5)=C(OC(F)F)C=C4

-20°C

Ice Packs

Small Compound