Tanshinone IIB - CAS 17397-93-2

Co-treatment with Tanshinone IIB (TSB) significantly inhibits the DNA laddering, cytotoxicity and apoptosis of rat cortical neurons induced by staurosporine in a concentration-dependent manner; TSB also suppresses the elevated Bax protein and decreased bcl-2 and caspase-3 proteins induced by staurosporine in rat cortical neurons; TSB is effective in reducing stroke-induced brain damage and may represent a novel drug candidate for further development.

Bcl-2 Family, Apoptosis, Caspase, P-gp

Apoptosis, Proteases/Proteasome, Neuroscience, Membrane transporter/Ion channel

17302

C19H18O4

310.349

Cc1coc-2c1C(=O)C(=O)c1c3CCC[C@](C)(CO)c3ccc-21

-20°C

Ice Packs

Natural Product