TAS2940 free base - CAS 2451398-65-3

TAS2940 is an irreversible pan-ERBB inhibitor with enhanced brain penetration, utilized for treating lung cancer brain metastases and glioblastomas with HER2/EGFR exon 20 insertions and EGFR abnormalities. In intracranial xenograft models of HER2/EGFR cancers, TAS2940 has demonstrated efficacy in improving survival rates in mice. Currently, TAS2940 is undergoing Phase I clinical trials to establish the maximum tolerated dose for solid tumors.

EGFR

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

2451330

C28H30N6O2

482.58

C(#CC1CC1)C=2N(C=3C(C2C(N[C@H](C)C4=CC=CC=C4)=O)=C(N)N=CN3)[C@H]5CN(C(C=C)=O)[C@@H](C)C5

-20°C

Ice Packs

Small Compound