TAS2940 fumarate - CAS 2758034-98-7

TAS2940 fumarate is a brain-penetrating, orally active, irreversible, and selective pan-ERBB inhibitor. It exhibits IC50 values of 5.6 nM, 2.1 nM, and 1.0 nM against wild-type HER2, HER2 V777L, and A775_G776insYVMA, respectively. TAS2940 fumarate is utilized for researching tumors characterized by abnormalities in HER2 and EGFR.

EGFR

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

2758034-98-7

C32H34N6O6

598.65

C(=C/C(O)=O)\C(O)=O.C(#CC1CC1)C=2N(C=3C(C2C(N[C@H](C)C4=CC=CC=C4)=O)=C(N)N=CN3)[C@H]5CN(C(C=C)=O)[C@@H](C)C5

-20°C

Ice Packs

Small Compound