Taurolithocholic acid - CAS 516-90-5

Taurolithocholic acid 3-sulfate (TLC-S) induces Ca2+ signaling in isolated murine pancreatic acinar cells (PACs) . Ca2+ oscillations occur at concentrations as low as 25 μM and are triggered in nearly all cells at 200 μM. At 300–500 μM, Taurolithocholic produces prolonged Ca2+ elevations that begin with intracellular Ca2+ release and are sustained by extracellular Ca2+ influx. Other bile salts, including taurodeoxycholate (TDC) and taurocholate (TC), can also stimulate local and global Ca2+ oscillations but only at much higher concentrations (approximately 1 mM and 5 mM) . Taurolithocholic is a potent Ca2+-releasing bile acid tested in PACs and is uniquely effective at inducing Ca2+-independent ionic currents even at low micromolar levels. Therefore implicating Taurolithocholic as a strong canidate for researches in gut metabolism.

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421

C26H45NO5S

483.7

C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](CC3)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]

-20°C

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