TBK1-IN-2 - CAS 3075572-35-6

TBK1-IN-2 (Compound A1) is a potent inhibitor of TBK1 with an IC50 of 775 pM. It binds to TBK1 through stable hydrogen bonding and π-π stacking interactions, thereby inhibiting the phosphorylation of IRF3. TBK1-IN-2 works in synergy with TNF/IFNγ to enhance immune-mediated tumor cell death and is applicable in cancer immunotherapy research.

IκB/IKK

NF-κB

3075531

C26H29N7O5

519.55

O=C(OCC=1C=CC=CC1)NC2CCN(C(=O)NC3=CNN=C3C4=NC=5C=C(OC)C(OC)=CC5N4)CC2

-20°C

Ice Packs

Small Compound