TC13172 - CAS 2093393-05-4

TC13172 is a potent and covalent inhibitor that specifically targets the mixed lineage kinase domain-like protein (MLKL), exhibiting significant selectivity for MLKL over the closely related receptor-interacting serine/threonine kinase 1 (RIPK1) and RIPK3 at a concentration of 10 μM.TC13172 effectively inhibits necroptosis induced by the TSZ combination (TNF-α, a Smac mimetic, and Z-VAD-FMK) in HT-29 cells with a EC50 of 2 nM and, at 100 nM, blocks TSZ-induced oligomerization and plasma membrane translocation of MLKL.

MLK

MAPK

2093393-05-4

C17H16N4O5S

388.4

O=C1C2=C(N=C(N2C)S(=O)(=O)C)N(C(=O)N1C)CC#CC=3C=CC=C(O)C3

-20°C

Ice Packs

Small Compound