TCL1 - CAS 875165-39-2

TCL1 acts as a selective non-covalent inhibitor targeting the Pru domain of the Rpn-13 subunit within the 19S regulatory particle (19S RP) of the proteasome, with an IC50 value around 26 μM. It disrupts the recognition and transport of ubiquitinated proteins by Rpn-13, thus inhibiting proteasomal degradation and affecting intracellular protein metabolism balance. TCL1 holds potential for research in hematologic malignancies.

Proteasome

Proteases/Proteasome, Ubiquitination

875124

C19H14BrClN4O2S

477.762

O=C(O)CC1SC2=NN=C(N2N=C1C=3C=CC(Cl)=CC3)CC4=CC=C(Br)C=C4

-20°C

Ice Packs

Small Compound