TCL1 (10-24) - CAS 835655-37-3

TCL1 (10-24) is an Akt inhibitor encompassing the betaA strand of human TCL1. It interacts with the Akt PH domain, preventing phosphoinositide binding and thereby inhibiting membrane translocation and activation of Akt. TCL1 (10-24) inhibits cellular proliferation and anti-apoptosis, demonstrating its capacity to suppress tumor growth in vivo [1].

Apoptosis, Akt

Apoptosis, PI3K/Akt/mTOR signaling, Cytoskeletal Signaling

835655-37-3

C88H123N23O23

1871.06

C([C@@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)CCCCN)=O)CCC(O)=O)=O)NC([C@@H](NC([C@H](CC=2C=3C(NC2)=CC=CC3)NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]4N(C([C@H](CC5=CN=CN5)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](C)N)=O)C(C)C)=O)[C@@H](C)O)=O)CC(O)=O)=O)=O)CCC4)CC(O)=O)=O)CCCNC(=N)N)=O)CC(C)C)=O)=O)C)=O)C=6C=7C(NC6)=CC=CC7

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