TCN 237 hydrochloride - CAS 1784252-90-9

TCN 237 serves as an antagonist of NR2B subunit-containing NMDA receptors, with a Ki value of 0.85 nM. It specifically blocks glutamate and glycine-induced currents in whole-cell patch-clamp assays when using L-M (TK-) cells expressing NR2B subunit-containing NMDA receptors. This is in contrast to its effect on L-M (TK-) cells with NR2A- or NR2D subunit-containing receptors and HEK293 cells with NR2C subunit-containing receptors. Additionally, TCN 237 at 3 mg/kg dosage mitigates carrageenan-induced mechanical hyperalgesia in rats.

Others, iGluR

Others, Neuroscience, Membrane transporter/Ion channel

1784153

C20H24Cl2FN3O

412.33

FC1=C(CC2CCN(CC2)CC3=NC4=C(N3)C=CC(O)=C4)C=CC=C1.Cl.Cl

-20°C

Ice Packs

Small Compound