TCS 21311 - CAS 1260181-14-3

TCS 21311 (NIBR3049) is an effective and highly selective inhibitor of JAK3 (IC50: 8 nM) . TCS 21311 inhibits PKCα, PKCθ, and GSK3β (IC50s: 13, 68, and 3 nM, respectively) . It displays >100-fold selectivity over JAK1, JAK2, and TYK2.

JAK, GSK-3, PKC

PI3K/Akt/mTOR signaling, Tyrosine Kinase/Adaptors, JAK/STAT signaling, Cytoskeletal Signaling, Chromatin/Epigenetic, Angiogenesis, Stem Cells

1260164

0.9939

C27H25F3N4O4

526.51

CC(C)(O)C(=O)N1CCN(CC1)c1ccc(c(c1)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12)C(F)(F)F

-20°C

Ice Packs

Small Compound