TD-004 - CAS 2351915-38-1

TD-004 (HC58-111) is an innovative degrader of anaplastic lymphoma kinase (ALK) fusion proteins, effectively promoting the degradation of ALK proteins. It inhibits the growth of ALK fusion-positive cell lines SU-DHL-1 and H3122, and significantly reduces tumor growth in H3122 xenograft models.

2351876

C55H70ClN9O8S2

1084.78

N(C1=C(OC(C)C)C=C(C(C)=C1)C2CCN(C(CCCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C5=C(C)N=CS5)=O)C[C@H](O)C3)[C@](C)(C)C)=O)=O)CC2)C=6N=C(NC7=C(S(C(C)C)(=O)=O)C=CC=C7)C(Cl)=CN6

-20°C

Ice Packs

Small Compound