TD114-2 - CAS 436866-52-3

TD114-2 (compound 29) is a potent and highly selective inhibitor of glycogen synthase kinase-3β (GSK-3β) with an IC50 of 48 nM. It forms a hydrogen bond with Arginine 141 (ARG141) in GSK-3β, an amino acid often found as a negatively charged residue in other kinases, contributing to its high selectivity. TD114-2 is applicable for research on diabetes, neurodegenerative diseases, and other conditions related to GSK-3β.

GSK-3

PI3K/Akt/mTOR signaling, Stem Cells

436866-52-3

C30H31N3O6

529.58

O=C1NC(=O)C=2C3=CN(C=4C=CC=CC34)CCOCCOCCOCCOCCN5C=C(C=6C=CC=CC65)C12

-20°C

Ice Packs

Small Compound