Tebufelone - CAS 112018-00-5

Tebufelone is a potent in vitro inhibitor of CO , a novel non-steroidal anti-inflammatory drug (NSAID) belonging to the di-tert-butylphenol (DTBP) class that has shown potent anti-inflammatory, analgesic and anti-reticulitis properties in various animal models. Tebufelone potently inhibits the formation of prostaglandins (PGE2) and blocks the formation of lipoxygenase pathway products [leukotriene (LTB4) ] in rat macrophages (IC50 = 20 microM) and human whole blood (IC50 = 22 microM) in vitro. = 20 microM) and human whole blood (IC50 = 22 microM) from the formation of lipoxygenase pathway products [leukotriene (LTB4) ] in vitro.

COX, LTR, Prostaglandin Receptor, Lipoxygenase

Metabolism, Neuroscience, GPCR/G Protein, Immunology/Inflammation

112018-00-5

0.9961

C20H28O2

300.44

OC1=C(C(C)(C)C)C=C(C(CCCC#C)=O)C=C1C(C)(C)C

-20°C

Ice Packs

Small Compound