Tenofovir exalidex - CAS 911208-73-6

Tenofovir exalidex (CMX 157) is a lipid-conjugated acyclic nucleotide analog of Tenofovir, demonstrating efficacy against wild-type and antiretroviral-resistant HIV strains, including those resistant to multiple nucleoside/nucleotide analogs. It effectively inhibits all major HIV-1 and HIV-2 subtypes in fresh human PBMCs, as well as all evaluated HIV-1 strains in monocyte-derived macrophages, displaying EC50 values between 0.2 and 7.2 nM. Oral administration of CMX157 shows no apparent toxicity. Additionally, Tenofovir exalidex exhibits antiviral properties against HBV.

HBV, Nucleoside Antimetabolite/Analog, Antiviral, HIV Protease

DNA Damage/DNA Repair, Immunology/Inflammation, Microbiology/Virology, Proteases/Proteasome, Cell Cycle/Checkpoint

911208-73-6

0.9983

C28H52N5O5P

569.72

C([C@H](OCP(OCCCOCCCCCCCCCCCCCCCC)(=O)O)C)N1C=2C(N=C1)=C(N)N=CN2

-20°C

Ice Packs

Small Compound