Terpendole I - CAS 167612-17-1

Terpendole I is a fungal metabolite that has been found in A. yamanashiensis.1 It is a weak inhibitor of acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 145 μM) and is active against the bacteria B. cereus and B. subtilis (MICs = 100 μg/ml for both) but not S. aureus, P. aeruginosa, or K. pneumoniae (MICs = >200 μg/ml for all) or the fungus C. albicans (MIC = 200 μg/ml) .1,2 It is cytotoxic to HeLa cells with an IC50 value of 52.6 μM.3

Others, Endogenous Metabolite, Acyltransferase

Others, Metabolism

167594

C27H35NO5

453.579

[H][C@]12Cc3c([nH]c4ccccc34)[C@]1(C)[C@@]1(C)CC[C@]3([H])O[C@@H]([C@@H](O)[C@H]4O[C@@]34[C@]1(O)CC2)C(C)(C)O

-20°C

Ice Packs

Natural Product