Tesevatinib tosylate - CAS 1000599-06-3

Tesevatinib tosylate (XL-647 tosylate) is an orally administered epidermal growth factor receptor (EGFR) inhibitor that can cross the blood-brain barrier. It significantly reduces cell viability with IC50 values of 11 nM and 102 nM in GBM12 and GBM6, respectively. Additionally, Tesevatinib tosylate inhibits HER2 (IC50=16.1 nM), VEGFR2 (IC50=1.5 nM), and Src (IC50=10.3 nM), demonstrating antitumor activity by inhibiting tumor proliferation.

Src, EGFR, VEGFR

Angiogenesis, JAK/STAT signaling, Tyrosine Kinase/Adaptors

1000599-06-3

C31H33Cl2FN4O5S

663.59

S(=O)(=O)(O)C1=CC=C(C)C=C1.N(C=1C2=C(C=C(OC[C@@H]3C[C@]4([C@@](C3)(CN(C)C4)[H])[H])C(OC)=C2)N=CN1)C5=C(F)C(Cl)=C(Cl)C=C5

-20°C

Ice Packs

Small Compound