Tetrac - CAS 67-30-1

Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac blocks the effects of T4 and 3,5,3'-triiodo-L-thyronine (T3) on the cell-surface thyroxine integrin αvβ3 receptors.Tetra has anti-angiogenic, anti-tumor activity and pro-apoptotic activity.

EGFR, Integrin, Apoptosis, Endogenous Metabolite

Angiogenesis, Cytoskeletal Signaling, JAK/STAT signaling, Tyrosine Kinase/Adaptors, Metabolism, Apoptosis

36

0.9904

C14H8I4O4

747.83

OC(=O)Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1

-20°C

Ice Packs

Natural Product