Tetrachlorohydroquinone - CAS 87-87-6

Tetrachlorohydroquinone (TCHQ), a metabolite of the organochlorine biocide pentachlorophenol, is cytotoxic to RTL-W1 rainbow trout liver cells (EC50 = 1.55 μM in a neutral red assay) . TCHQ increases production of reactive oxygen species (ROS), inhibits apoptosis, and induces loss of mitochondrial membrane potential and necrosis in splenocytes.

Necroptosis, Reactive Oxygen Species, Apoptosis, ROS, Drug Metabolite, Others

NF-κB, Others, Apoptosis, Immunology/Inflammation, Metabolism

-6

C6H2Cl4O2

247.89

Oc1c(Cl)c(Cl)c(O)c(Cl)c1Cl

-20°C

Ice Packs

Small Compound