Tetrahydrocoptisine - CAS 4312-32-7

1. Tetrahydrocoptisine (STYLOPINE) has effective effects in suppressing inflammation. 2. Tetrahydrocoptisine possesses a protective effect on LPS-induced ALI through inhibiting of NF-κB signaling pathways, which may involve the inhibition of pulmonary inflammatory process. 3. Tetrahydrocoptisine has gastroprotective activity, is attributed to reducing NO production and adjusting the pro-inflammatory cytokine, inhibited neutrophil accumulation and NF-κB expression. 4. Tetrahydrocoptisine is an active anti-inflammatory constituent by inhibition of TNF-α, IL-6 and NO production possibly via down-regulation of NF-κB activation, phospho-ERK1/2 and phospho-p38MAPK signal pathways.

PERK, Interleukin, p38 MAPK, NF-κB, ERK, Parasite, NO Synthase

Microbiology/Virology, Immunology/Inflammation, Apoptosis, NF-κB, MAPK

4273

0.9976

C19H17NO4

323.34

C1Oc2cc3CCN4Cc5c6OCOc6ccc5CC4c3cc2O1

-20°C

Ice Packs

Natural Product