TFGF-18 - CAS 2222662-20-4

TFGF-18 is a GSK-3β inhibitor with an IC50 of 0.59 μM. It suppresses microglial activation and the release of pro-inflammatory mediators induced by LPS by inhibiting GSK-3β and downstream p65/NF-κB signaling. TFGF-18 also prevents neuronal apoptosis and oxidative stress, reduces the expression of Bax, caspase-3, and cleaved-caspase-3, while increasing Bcl-2 expression. It offers neuroprotection by inhibiting neuroinflammation and alleviating cognitive impairment.

GSK-3, Apoptosis, Reactive Oxygen Species, Bcl-2 Family, Caspase

Proteases/Proteasome, Apoptosis, NF-κB, PI3K/Akt/mTOR signaling, Metabolism, Stem Cells, Immunology/Inflammation

2222638

C28H30F3NO11

613.53

O(C)C=1C(=C(OC)C=C2C1C(=O)C=C(O2)C3=CC(OC)=C(OC)C=C3)[C@@H]4O[C@H](C(N[C@H](C(F)(F)F)C)=O)[C@@H](O)[C@H](O)[C@H]4O

-20°C

Ice Packs

Small Compound