TG-100435 - CAS 867330-68-5

TG-100435 is a novel multi-target oral protein tyrosine kinase inhibitor. The metabolic flux of TG100435 is entirely inhibited by methimazole and ketoconazole. In human liver microsomes or recombinant P450, the formation of TG100435 increases with the activity of cytochrome P450 reductase, suggesting that cytochrome P450 reductase may be involved.

Ephrin Receptor, Bcr-Abl, Src

Cytoskeletal Signaling, Angiogenesis, Tyrosine Kinase/Adaptors

867257

C26H25Cl2N5O

494.42

ClC=1C=CC=C(Cl)C1C2=CC=3N=NC(=NC3C(=C2)C)NC4=CC=C(OCCN5CCCC5)C=C4

-20°C

Ice Packs

Small Compound