TG6-129 - CAS 1164464-14-5

TG6-129 is an antagonist of the EP2 receptor. TG6-129 suppresses PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM. TG6-129 reduces the expression of COX-2, IL-1β, IL-6, IL-12, IL-23 and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages.

Prostaglandin Receptor

GPCR/G Protein, Immunology/Inflammation

1164445

0.9955

C20H18FN5O3S3

491.58

CCC1=NN=C(NS(=O)(=O)C2=CC=C(NC(=S)NC(=O)\C=C\C3=CC=C(F)C=C3)C=C2)S1

-20°C

Ice Packs

Small Compound