TGase2-IN-1 - CAS 2244702-64-3

TGase2-IN-1 (Compound 22) is an orally effective TGase2 inhibitor with an IC50 of 1.12 μM. It inhibits TGase2 in human retinal microvascular endothelial cells with a strikingly lower IC50 of 0.07 μM. The oral bioavailability of TGase2-IN-1 is 74.6%. Additionally, it can suppress retinal vascular leakage in a mouse model of diabetes induced by Streptozotocin.

Glutaminase, Ligands for Target Protein for PROTAC

Proteases/Proteasome, PROTAC

2244635

C23H25N3O3

391.46

O=C1C=C(N)C(=O)C2=NC(=CC=C12)C=3C=CC(OC4CCN(CC4)C(C)C)=CC3

-20°C

Ice Packs

Small Compound